RCT characteristics

The database includes a total of 354 RCTs from 38 different countries. These RCTs were published in 126 different journals in 8 languages between 1986 and 2017.


Trial characteristics Results
Design -
Pilot trial 44 of 354 (12.4%)
Medication intervention 206 of 354 (58.2%)
Blinding reported 182 of 354 (51.4%)
High risk of bias 159 of 354 (44.9%)
Centres -
Multicentred 70 of 354 (19.8%)
Number of centres in multicentred 5.5 (2, 15) min=2 max=104 n=70
Countries -
Multinational 28 of 354 (7.9%)
International collaboration 63 of 354 (17.8%)
Funding -
Any funding reported 177 of 354 (50.0%)
Any commercial funding reported 46 of 354 (13.0%)
Results -
Total children randomized 44048
Children randomized per RCT 51 (32.2, 101) min=6 max=4947 n=354
Children analyzed 50 (30, 98) min=6 max=4947 n=339
Stopped early 47 of 174 (27.0%)
Results statistically significant 84 of 216 (38.9%)
Impact -
Journal impact factor 3.8 (2.3, 6.3) min=0.4 max=55.9 n=296
Citations per year 1.7 (0.7, 3.3) min=0 max=37.5 n=289

Children randomized per RCT

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.


Types of interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Indication for interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Population studied

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Report generated: 31-May-17 at 13:11h
Database version: 2017Q1
Date of last searches: 10-Apr-17