RCT characteristics

The database includes a total of 415 RCTs from 41 different countries. These RCTs were published in 148 different journals in 8 languages between 1986 and 2018.


Trial characteristics Results
Design -
Pilot trial 60 of 415 (14.5%)
Medication intervention 232 of 415 (55.9%)
Blinding reported 206 of 415 (49.6%)
High risk of bias 202 of 415 (48.7%)
Centres -
Multicentred 78 of 415 (18.8%)
Number of centres in multicentred 5.5 (2, 15) min=2 max=104 n=78
Countries -
Multinational 28 of 415 (6.7%)
International collaboration 66 of 415 (15.9%)
Funding -
Any funding reported 207 of 415 (49.9%)
Any commercial funding reported 46 of 415 (11.1%)
Results -
Total children randomized 49721
Children randomized per RCT 55 (35, 101) min=6 max=4947 n=415
Children analyzed 50 (32, 100) min=6 max=4947 n=397
Stopped early 58 of 218 (26.6%)
Results statistically significant 100 of 249 (40.2%)
Impact -
Journal impact factor 3.2 (2.3, 6.6) min=0.2 max=79.3 n=369
Citations per year 1.8 (0.6, 3.4) min=0 max=43.4 n=401

Children randomized per RCT

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.


Types of interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Indication for interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Population studied

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Report generated: 26-Feb-19 at 15:50h
Database version: 2018Q4
Date of last searches: 04-Jan-19