## RCT characteristics

The database includes a total of 365 RCTs from 38 different countries. These RCTs were published in 130 different journals in 8 languages between 1986 and 2017.

Trial characteristics | Results |
---|---|

Design |
- |

Pilot trial | 48 of 365 (13.2%) |

Medication intervention | 214 of 365 (58.6%) |

Blinding reported | 189 of 365 (51.8%) |

High risk of bias | 164 of 365 (44.9%) |

Centres |
- |

Multicentred | 71 of 365 (19.5%) |

Number of centres in multicentred | 6 (2, 15) min=2 max=104 n=71 |

Countries |
- |

Multinational | 28 of 365 (7.7%) |

International collaboration | 65 of 365 (17.8%) |

Funding |
- |

Any funding reported | 178 of 365 (48.8%) |

Any commercial funding reported | 46 of 365 (12.6%) |

Results |
- |

Total children randomized | 44834 |

Children randomized per RCT | 51 (33, 101) min=6 max=4947 n=365 |

Children analyzed | 50 (30.5, 97.5) min=6 max=4947 n=350 |

Stopped early | 49 of 182 (26.9%) |

Results statistically significant | 84 of 226 (37.2%) |

Impact |
- |

Journal impact factor | 3.8 (2.2, 6.3) min=0.4 max=55.9 n=302 |

Citations per year | 1.7 (0.7, 3.3) min=0 max=37.5 n=289 |

### Children randomized per RCT

```
require(ggplot2)
x_limits_year <- as.numeric(c(1985, current_year))
x_limits_year[2] <- x_limits_year[2] +1
ggplot(RCT, aes(RCT$Date__Publication__Year_c, RCT$Num__Rand__Total_c)) +
geom_hline(yintercept = median(RCT$Num__Rand__Total_c), colour = "red") +
geom_hline(yintercept = quantile(RCT$Num__Rand__Total_c, 0.25), colour = "red", linetype = "dashed") +
geom_hline(yintercept = quantile(RCT$Num__Rand__Total_c, 0.75), colour = "red", linetype = "dashed") +
geom_point(shape = 1, position = position_jitter(height = 0),na.rm = TRUE) +
coord_trans(y = "log") +
scale_x_continuous(breaks = seq(1985, as.numeric(current_year), 5), limits = x_limits_year) +
scale_y_continuous(breaks = c(10, 25, 50, 100, 250, 500, 1000, 2500, 5000), limits = c(6, 5000)) +
labs(x = "Year of publication",
y = "Children randomized") +
theme_bw() +
theme_plot # my custom theme (defined in functions file)
```

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1^{st} and 3^{rd} quartile.

### Types of interventions tested

```
require(ggplot2)
make.treemap(intervention, "Set2")
```

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.

### Indication for interventions tested

```
require(ggplot2)
make.treemap(indication, "Set3")
```

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.

### Population studied

```
require(ggplot2)
make.treemap(population, "Paired")
```

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.

Report generated: 20-Aug-17 at 16:47h

Database version: 2017Q2

Date of last searches: 03-Jul-17