RCT characteristics

The database includes a total of 432 RCTs from 42 different countries. These RCTs were published in 153 different journals in 8 languages between 1986 and 2019.


Trial characteristics Results
Design -
Pilot trial 65 of 432 (15.0%)
Medication intervention 240 of 432 (55.6%)
Blinding reported 214 of 432 (49.5%)
High risk of bias 212 of 432 (49.1%)
Centres -
Multicentred 80 of 432 (18.5%)
Number of centres in multicentred 5 (2, 15) min=2 max=104 n=80
Countries -
Multinational 29 of 432 (6.7%)
International collaboration 70 of 432 (16.2%)
Funding -
Any funding reported 216 of 432 (50.0%)
Any commercial funding reported 47 of 432 (10.9%)
Results -
Total children randomized 51941
Children randomized per RCT 56 (36, 101.5) min=6 max=4947 n=431
Children analyzed 50.5 (32.8, 100) min=6 max=4947 n=412
Stopped early 60 of 230 (26.1%)
Results statistically significant 105 of 259 (40.5%)
Impact -
Journal impact factor 3 (2.1, 7) min=0.2 max=70.7 n=385
Citations per year 1.8 (0.6, 3.6) min=0 max=44.6 n=418

Children randomized per RCT

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.


Types of interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Indication for interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Population studied

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Report generated: 13-Sep-19 at 15:01h
Database version: 2019Q2
Date of last searches: 02-Jul-19