RCT characteristics
The database includes a total of 365 RCTs from 38 different countries. These RCTs were published in 130 different journals in 8 languages between 1986 and 2017.
| Trial characteristics | Results |
|---|---|
| Design | - |
| Pilot trial | 48 of 365 (13.2%) |
| Medication intervention | 214 of 365 (58.6%) |
| Blinding reported | 189 of 365 (51.8%) |
| High risk of bias | 164 of 365 (44.9%) |
| Centres | - |
| Multicentred | 71 of 365 (19.5%) |
| Number of centres in multicentred | 6 (2, 15) min=2 max=104 n=71 |
| Countries | - |
| Multinational | 28 of 365 (7.7%) |
| International collaboration | 65 of 365 (17.8%) |
| Funding | - |
| Any funding reported | 178 of 365 (48.8%) |
| Any commercial funding reported | 46 of 365 (12.6%) |
| Results | - |
| Total children randomized | 44834 |
| Children randomized per RCT | 51 (33, 101) min=6 max=4947 n=365 |
| Children analyzed | 50 (30.5, 97.5) min=6 max=4947 n=350 |
| Stopped early | 49 of 182 (26.9%) |
| Results statistically significant | 84 of 226 (37.2%) |
| Impact | - |
| Journal impact factor | 3.8 (2.2, 6.3) min=0.4 max=55.9 n=302 |
| Citations per year | 1.7 (0.7, 3.3) min=0 max=37.5 n=289 |
Children randomized per RCT
require(ggplot2)
x_limits_year <- as.numeric(c(1985, current_year))
x_limits_year[2] <- x_limits_year[2] +1
ggplot(RCT, aes(RCT$Date__Publication__Year_c, RCT$Num__Rand__Total_c)) +
geom_hline(yintercept = median(RCT$Num__Rand__Total_c), colour = "red") +
geom_hline(yintercept = quantile(RCT$Num__Rand__Total_c, 0.25), colour = "red", linetype = "dashed") +
geom_hline(yintercept = quantile(RCT$Num__Rand__Total_c, 0.75), colour = "red", linetype = "dashed") +
geom_point(shape = 1, position = position_jitter(height = 0),na.rm = TRUE) +
coord_trans(y = "log") +
scale_x_continuous(breaks = seq(1985, as.numeric(current_year), 5), limits = x_limits_year) +
scale_y_continuous(breaks = c(10, 25, 50, 100, 250, 500, 1000, 2500, 5000), limits = c(6, 5000)) +
labs(x = "Year of publication",
y = "Children randomized") +
theme_bw() +
theme_plot # my custom theme (defined in functions file)
The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.
Types of interventions tested
require(ggplot2)
make.treemap(intervention, "Set2")
The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.
Indication for interventions tested
require(ggplot2)
make.treemap(indication, "Set3")
The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.
Population studied
require(ggplot2)
make.treemap(population, "Paired")
The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.
Report generated: 20-Aug-17 at 16:47h
Database version: 2017Q2
Date of last searches: 03-Jul-17