RCT characteristics

The database includes a total of 372 RCTs from 39 different countries. These RCTs were published in 133 different journals in 8 languages between 1986 and 2017.


Trial characteristics Results
Design -
Pilot trial 51 of 372 (13.7%)
Medication intervention 218 of 372 (58.6%)
Blinding reported 192 of 372 (51.6%)
High risk of bias 169 of 372 (45.4%)
Centres -
Multicentred 72 of 372 (19.4%)
Number of centres in multicentred 5.5 (2, 15) min=2 max=104 n=72
Countries -
Multinational 28 of 372 (7.5%)
International collaboration 65 of 372 (17.5%)
Funding -
Any funding reported 183 of 372 (49.2%)
Any commercial funding reported 46 of 372 (12.4%)
Results -
Total children randomized 45290
Children randomized per RCT 51 (32.8, 100.2) min=6 max=4947 n=372
Children analyzed 50 (30, 96) min=6 max=4947 n=356
Stopped early 52 of 188 (27.7%)
Results statistically significant 88 of 225 (39.1%)
Impact -
Journal impact factor 3.7 (2.1, 6.3) min=0.4 max=55.9 n=305
Citations per year 1.7 (0.7, 3.3) min=0 max=37.5 n=289

Children randomized per RCT

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.


Types of interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Indication for interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Population studied

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Report generated: 13-Nov-17 at 11:18h
Database version: 2017Q3
Date of last searches: 10-Oct-17