RCT characteristics

The database includes a total of 444 RCTs from 42 different countries. These RCTs were published in 155 different journals in 8 languages between 1986 and 2020.


Trial characteristics Results
Design -
Pilot trial 66 of 444 (14.9%)
Medication intervention 242 of 444 (54.5%)
Blinding reported 220 of 444 (49.5%)
High risk of bias 221 of 444 (49.8%)
Centres -
Multicentred 82 of 444 (18.5%)
Number of centres in multicentred 5 (2, 15) min=2 max=104 n=82
Countries -
Multinational 30 of 444 (6.8%)
International collaboration 75 of 444 (16.9%)
Funding -
Any funding reported 223 of 444 (50.2%)
Any commercial funding reported 47 of 444 (10.6%)
Results -
Total children randomized 54433
Children randomized per RCT 57 (36, 101.5) min=6 max=4947 n=443
Children analyzed 51 (33.8, 100) min=6 max=4947 n=424
Stopped early 60 of 238 (25.2%)
Results statistically significant 108 of 267 (40.4%)
Impact -
Journal impact factor 3 (2.1, 7) min=0.2 max=70.7 n=395
Citations per year 1.8 (0.6, 3.6) min=0 max=44.6 n=418

Children randomized per RCT

The solid red line shows the overall median number of children randomized per RCT and the dashed red lines show the 1st and 3rd quartile.


Types of interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Indication for interventions tested

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Population studied

The area of each block is proportional to the number of RCTs in that category. The number in parentheses is the number of RCTs in that category.


Report generated: 04-Feb-20 at 11:35h
Database version: 2019Q4
Date of last searches: 03-Jan-20