Welcome to the PIC-UP Pilot Trial
The Pediatric Intensive Care Ulcer Prophylaxis Pilot Trial is a multi-centre randomized controlled pilot trial (RCT) testing the feasibility of a large multicentre RCT of stress ulcer prophylaxis to prevent upper gastrointestinal bleeding in critically ill children.
The PIC-UP Pilot trial is underway at 7 Canadian PICUs. It is a project of the Canadian Critical Care Trials Group.
This pilot trial is part of a program of research leading to a large trial to determine if a strategy of withholding stress ulcer prophylaxis in critically ill children is not inferior to a strategy of routine stress ulcer prophylaxis with pantoprazole.
We hypothesize that withholding stress ulcer prophylaxis will not result in an unacceptable increase in upper GI bleeding. An important secondary hypothesis is that there will be fewer nosocomial infections (ventilator-associated pneumonia and C difficile-associated diarrhea) in the group who do not receive prophylaxis.
Trial registration: NCT02929563