Publications

These publications have used PICUtrials.net to identify randomized controlled trials in pediatric critical care or used data from the database.
(Updated 10-May-19).

Journal articles

  1. Matics TJ, Khan N, Jani P, Kane JM. The Fragility of Statistically Significant Findings in Pediatric Critical Care Randomized Controlled Trials. Pediatric Critical Care Medicine. 2019 Apr.
    PubMed | Journal Website
  2. Duffett M, Swinton M, Brouwers M, Meade MO, Cook DJ. Advancing randomized controlled trials in pediatric critical care: The perspectives of trialists. Pediatric Critical Care Medicine. 2018 Nov;19(11):e595-602.
    PubMed | Journal Website
  3. Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Cook DJ. Need for a randomized controlled trial of stress ulcer prophylaxis in critically ill children: a Canadian survey. The Canadian journal of hospital pharmacy. 2017 Jul;70(4):288.
    PubMed Journal Website
  4. Wulff A, Marschollek M. Learning Healthcare Systems in Pediatrics: Cross-Institutional and Data-Driven Decision-Support for Intensive Care Environments (CADDIE). Studies in health technology and informatics. 2018 Jan;251:109-12.
    PubMed Journal Website
  5. Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, et al. High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators. Pediatric Critical Care Medicine. 2017 May;18(5):405–13.
    PubMed | Journal Website
  6. Menon K, McNally JD, Zimmerman JJ, Agus MSD, O'Hearn K, Watson RS, et al. Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatric Critical Care Medicine. 2017 Mar;18(3):e146–54.
    PubMed Journal Website
  7. Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook DJ. Pilot Randomized Trials in Pediatric Critical Care: A Systematic Review. Pediatric Critical Care Medicine. 2015 Sep;16(7):e239–44.
    PubMed | Journal Website
  8. Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook DJ. Randomized controlled trials in pediatric critical care: a scoping review. Critical Care. 2013 Oct 29;17(5):R256.
    PubMed Journal Website

Abstracts and posters

  1. Xu G, deWildt S, Zavalkoff S, Duffett M. Gender disparities in pediatric critical care research. Toronto; November 2018. Critical Care Canada Forum.
    Abstract | Poster
  2. Caldwell D, James M, Raja P, Duffett M. Sedative weaning and discontinuation in pediatric critical care: a scoping review. Pediatric Critical Care Medicine. 2018:19(6S):196.
    Abstract | Poster | Journal Website
  3. Duffett M, Brouwers M, Meade MO, Cook DJ. Research collaboration in pediatric critical care: a social network analysis of coauthorship. Pediatric Critical Care Medicine. 2018:19(6S):148-149.
    Abstract | PosterJournal Website
  4. Duffett M, Xu G, Cook DJ. Early stopping of randomized controlled trials in pediatric critical care. Pediatric Critical Care Medicine. 2018:19(6S):18-19.
    Abstract | Journal Website
  5. Choong K, Duffett M, Cook DJ, Randolph AG. The impact of clinical trials conducted by research networks in pediatric critical care. Pediatric Critical Care Medicine. 2016 Sep 1;17(9):837-44.
    Abstract | PosterJournal Website
  6. Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Cook DJ. Stress ulcer prophylaxis in critically ill children: A systematic review. Toronto; 2016. World Congress on Pediatric Intensive and Critical Care.
    Abstract | Poster
  7. Duffett M, Swinton M, Cook DJ. Improving randomized controlled trial evidence in pediatric critical care: the perspectives of trialists. Toronto; 2016. World Congress on Pediatric Intensive and Critical Care.
    AbstractPoster | Journal Website
  8. Duffett M, Choong K, Foster J, Meade MO, Menon K, Parker M, Cook DJ. Barriers and facilitators of high-quality RCTs in pediatric critical care: A survey of trialists. Critical Care Medicine. 2015 Dec;43(12):83.
    Abstract | Poster |  Journal Website
  9. Duffett M, Choong K, Hartling L, Thabane L, Cook D. International Collaboration in Pediatric Critical Care RCTs. Critical Care Medicine. 2014;42:A1449.
    AbstractPoster | Journal Website
  10. Choong K, Duffett M, Hanney I, Cook DJ, Randolph AG. Impact of Randomized Controlled Trials Conducted by Pediatric Critical Care Research Networks. Pediatric Critical Care Medicine. 2014;15(4):198-199.
    Abstract | Poster
  11. Hanney I, Duffett M, Choong K, Menon K, Cook DJ. Consent in Pediatric Critical Care Randomized Control Trails: A Systematic Review. Pediatric Critical Care Medicine. 2014 May;15:204.
    Abstract | Poster | Journal Website
  12. Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook DJ. Sample Size and Effect Estimates in Randomized Trials in Pediatric Critical Care: a Methodologic Review. Pediatric Critical Care Medicine. 2014;15(4 Suppl):29.
    Abstract
  13. Duffett M, Choong K, Cupido C, Hartling L, Menon K, Thabane L, Cook DJ. Risk of bias in pediatric critical care randomized controlled trials: a systematic review. 2013 Cochrane Colloquium, Quebec City, QC, Canada. September 19-23, 2013.
    Abstract | Poster
  14. Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook D. Commercial funding and results of pediatric critical care RCTs: A systematic Review. Critical Care Medicine. 2013;41(12):A139-A140.
    Abstract | Poster
  15. Duffett M, Choong K, Cupido C, Hartling L, Menon K, Thabane L, Cook DJ. Pilot randomized controlled trials in pediatric critical care: a systematic review. Intensive Care Medicine. 2013;39 Suppl 1:S54.
    AbstractPoster | Journal Website
  16. Duffett M, Choong K, Cupido C, Hartling L, Menon K, Thabane L, Cook DJ. Randomized Controlled Trials in Pediatric Critical Care: a Scoping Review. Critical Care Medicine. 2012; 12:162.
    Abstract | Poster | Journal Website

Citations

These publications have cited PICUtrials.net. See here.
(Updated 10-May-19).

  1. Barbaro RP, MacLaren G. Improving Pediatric Extracorporeal Cardiopulmonary Resuscitation Means Delivering Best Care and Measuring Impact Beyond Survival. Critical care medicine. 2019 Apr 1;47(4):613-5.
    PubMed Journal Website
  2. Jensen MM, Marker S, Do HQ, Perner A, Moller MH. Stress ulcer prophylaxis in critically ill children: Protocol for a systematic review. Acta Anaesthesiologica Scandinavica. 2019 Mar 25.
    PubMed Journal Website
  3. Liu A, Menon K. Contributions of a survey and retrospective cohort study to the planning of a randomised controlled trial of corticosteroids in the treatment of paediatric septic shock. Trials. 2018 Dec;19(1):283.
    PubMed Journal Website
  4. Thomas NJ, Spear D, Wasserman E, Pon S, Markovitz B, Singh AR, Li S, Gertz SJ, Rowan CM, Kunselman A, Tamburro RF. CALIPSO: A Randomized Controlled Trial of Calfactant for Acute Lung Injury in Pediatric Stem Cell and Oncology Patients. Biology of Blood and Marrow Transplantation. 2018 Dec 1;24(12):2479-86.
    PubMed 
    Journal Website
  5. Tricco AC, Lillie E, Zarin W, O'Brien KK, Colquhoun H, Levac D, Moher D, Peters MD, Horsley T, Weeks L, Hempel S. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Annals of internal medicine. 2018 Oct 2;169(7):467-73.
    PubMed Journal Website
  6. Wulff A, Haarbrandt B, Tute E, Marschollek M, Beerbaum P, Jack T. An interoperable clinical decision-support system for early detection of SIRS in pediatric intensive care using openEHR. Artificial intelligence in medicine. 2018 Jul 1;89:10-23.
    PubMed Journal Website
  7. Nie X, Guang P, Peng X. Critical components for designing and implementing randomized controlled trials. Pediatric Investigation. 2018 Jun;2(2):124-30.
    Journal Website
  8. Siemens K, Sangaran DP, Hunt BJ, Murdoch IA, Tibby SM. Strategies for prevention and management of bleeding following pediatric cardiac surgery on cardiopulmonary bypass: A scoping review. Pediatric Critical Care Medicine. 2018 Jan 1;19(1):40-7.
    PubMed Journal Website
  9. Drury NE, Patel AJ, Oswald NK, Chong CR, Stickley J, Barron DJ, Jones TJ. Randomized controlled trials in children’s heart surgery in the 21st century: a systematic review. European Journal of Cardio-Thoracic Surgery. 2017 Nov 23;53(4):724-31.
    PubMed Journal Website
  10. Midia M, Odedra D, Haider E, Shuster A, Muir J. Choosing Wisely Canada and diagnostic imaging: what level of evidence supports the recommendations?. Canadian Association of Radiologists Journal. 2017 Nov 1;68(4):359-67.
    PubMed Journal Website
  11. Bartoszko J, Vorobeichik L, Jayarajah M, Karkouti K, Klein AA, Lamy A, Mazer CD, Murphy M, Richards T, Englesakis M, Myles PS. Defining clinically important perioperative blood loss and transfusion for the Standardised Endpoints for Perioperative Medicine (StEP) collaborative: a protocol for a scoping review. BMJ open. 2017 Jun 1;7(6):e016743.
    PubMed Journal Website
  12. Menon K, McNally D, O’Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D. A randomized controlled trial of corticosteroids in pediatric septic shock: a pilot feasibility study. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2017 Jun;18(6):505.
    PubMed Journal Website
  13. Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ. Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot and Feasibility Studies. 2017 Dec;3(1):26.
    PubMed Journal Website
  14. Randolph AG. Why so few randomized trials in pediatric critical care medicine? Ask the trialists. Pediatric Critical Care Medicine. 2017 May 1;18(5):486-7.
    PubMed Journal Website
  15. Ricci Z, Romagnoli S, Di Chiara L. Latent AKI is… still AKI: the quantification of the burden of renal dysfunction. Critical Care. 2016 Dec;20(1):238.
    PubMed Journal Website
  16. Boulain T, Ehrmann S, Lakhal K. β-Blockade and Septic Shock Phenotype. Critical care medicine. 2016 May 1;44(5):e310-1.
    PubMed Journal Website
  17. Tasker RC, Akhondi-Asl A. Targeted Temperature Management After Cardiac Arrest Due to Drowning:“Frequentist” and “Bayesian” Decision Making. Pediatric Critical Care Medicine. 2016 Aug 1;17(8):789-91.
    PubMed Journal Website
  18. Kleiber N, Tromp K, Tibboel D, de Wildt SN. Trial Recruitment in the Pediatric Intensive Care: Ask Consent Before You Start. Critical Care Medicine. 2016 May 1;44(5):e309-310
    PubMed Journal Website
  19. Randolph AG. Pragmatic trials in critically ill children are CATCHing on. The Lancet. 2016 Apr 23;387(10029):1697-8.
    PubMed Journal Website
  20. Shime, N. Clinical and investigative critical care medicine in Japan. Intensive Care Medicine. 2016 Mar;42(3):453-55.
    PubMed Journal Website
  21. Tasker RC. Opportunities for enhancing patient recruitment in clinical research: building an evidence base for critical care medicine. Pediatric Critical Care Medicine. 2016 Mar 1;17(3):267-9.
    PubMed Journal Website
  22. Nama N, Menon K, Iliriani K, Pojsupap S, Sampson M, O’Hearn K, Zhou LL, McIntyre L, Fergusson D, McNally JD. A systematic review of pediatric clinical trials of high dose vitamin D. PeerJ. 2016 Feb 25;4:e1701.
    PubMed Journal Website
  23. Zimmerman JJ, Anand KJ, Meert KL, Willson DF, Newth CJ, Harrison R, Carcillo JA, Berger J, Jenkins TL, Nicholson C, Dean JM. Research as a Standard of Care in the PICU. Pediatric Critical Care Medicine. 2016 Jan 1;17(1):e13-21.
    PubMed Journal Website
  24. Sampaio TZ, O’Hearn K, Reddy D, Menon K. The influence of fluid overload on the length of mechanical ventilation in pediatric congenital heart surgery. Pediatric cardiology. 2015 Dec 1;36(8):1692-9.
    PubMed Journal Website
  25. Tromp K, Vathorst SV. Gatekeeping by professionals in recruitment of pediatric research participants: Indeed an undesirable practice. The American Journal of Bioethics. 2015 Nov 2;15(11):30-2.
    PubMed Journal Website
  26. Tromp K, Wildt S. Ethical aspects of clinical drug research in critically ill children. Nederlands tijdschrift voor geneeskunde. 2015 May;159:A8824.
    PubMed Journal Website
  27. Kleiber N, Tromp K, Mooij MG, VaN De VaTHOrST S, Tibboel D, De WilDT SN. Ethics of drug research in the pediatric intensive care unit. Pediatric Drugs. 2015 Feb 1;17(1):43-53.
    PubMed Journal Website
  28. Duffett M, Choong K, Vanniyasingam T, Thabane L, Cook DJ. Making decisions about medications in critically ill children: a survey of Canadian pediatric critical care clinicians. Pediatric Critical Care Medicine. 2015 Jan 1;16(1):21-8.
    PubMed Journal Website
  29. Bialy L, Vandermeer B, Lacaze‐Masmonteil T, Dryden DM, Hartling L. A meta‐epidemiological study to examine the association between bias and treatment effects in neonatal trials. Evidence‐Based Child Health: A Cochrane Review Journal. 2014 Dec;9(4):1052-9.
    PubMed Journal Website
  30. Kanthimathinathan HK, Scholefield BR. Dilemmas in undertaking research in paediatric intensive care. Archives of disease in childhood. 2014 Nov 1;99(11):1043-9.
    PubMed Journal Website
  31. Tasker RC. Update on pediatric neurocritical care. Pediatric Anesthesia. 2014 Jul;24(7):717-23.
    PubMed Journal Website
  32. Boyer DL, Randolph AG. Evidence-based Pediatric Critical Care Medicine. Pediatric Critical Care Medicine. 2014 Jan; (pp. 149-156). Springer, London.
    Journal Website
  33. Randolph AG. Rigorous scoping review of randomized trials in pediatric critical care highlights need for a rigorous rethink. Critical Care. 2013 Dec;17(6):1024.
    PubMed Journal Website